WebFerroptosis, a cell death process driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated in diseases such as ischaemic organ damage and cancer 1,2 . ... Huijie Bian 1 , Yong Li 1 , Brent R Stockwell 5 , Zhi-Nan Chen 6 , Xuejun Jiang 7 Affiliations 1 National Translational Science Center for Molecular Medicine ... http://www.columbia.edu/cu/biology/StockwellLab/index/pi-biography.html
Brent R. Stockwell, PhD Herbert Irving Comprehensive Cancer Center
WebAug 23, 2016 · Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid peroxidase, cause lethal accumulation of lipid peroxides and induce ferroptotic cell death. Although ferroptosis has bee … WebResolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against … brainerd mn to shoreview mn
10 Years On, a Cell Death Discovery Shows Promise for …
WebBrent R. Stockwell, Ph.D. Brent R. Stockwell grew up in Bay Terrace, a suburban neighborhood in New York City and graduated from Hunter College High School. He … WebFerroptosis: Death by Lipid Peroxidation Wan Seok Yang1,4,* and Brent R. Stockwell1,2,3,* Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides. This WebWe are using chemical and biological tools to study ferroptosis, a form of regulated cell death discovered in the Stockwell Lab. Ferroptosis is an iron-dependent form of oxidative, non-apoptotic cell death that is tightly … hacks for call of the wild