WebMar 11, 2024 · Cathepsin B (CTSB) is an exclusive multifunctional protein of cysteine protease family in that it has an additional pH sensitive occluding loop which allows it to … The CTSB gene is located at chromosome 8p22, consisting of 13 exons. The promoter of CTSB gene contains a GC-rich region including many SP1 sites, which is similar to housekeeping genes. At least five transcript variants encoding the same protein have been found for this gene. Cathepsin B is synthesized on the rough endoplasmic reticulum as a preproenzyme of 339 amino acids with a signal peptide of 17 amino acids. Procathepsin B of 43/46 kDa is then transported t…
13030 - Gene ResultCtsb cathepsin B [ (house mouse)]
WebThe CTSB gene is located at chromosome 8p22, consisting of 13 exons. The promoter of CTSB gene contains a GC-rich region including many SP1 sites, which is similar to housekeeping genes . [12] At least five transcript variants encoding the same protein have been found for this gene. WebFeb 8, 2012 · This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid … uhr conference 2021
CTSB Cancer Genetics Web
WebThe reliability score is divided into Enhanced, Supported, Approved, or Uncertain, and is displayed on both Tissue Atlas and Pathology Atlas. Antibodies used for this assay. Click on an antibody for more information. Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. WebAn siRNA containing a sequence that does not target any known mammalian gene was used as a control. The expression levels of HBSP and CTSB were analyzed by Western blotting, which showed marked reductions in HBSP and CTSB protein levels (Fig. 3a and andb) b) in HBSP-3 cells. Wound healing and transwell invasion assays were again used … WebMar 9, 2024 · The expressions of CTSB mRNA and protein in the cytosol were increased following HI insult (Figure S4A and Figure 4 A). The increased expression of CTSB was primarily in the Iba1 + microglia/macrophages, NeuN + neurons, and GFAP + astrocytes in the ipsilateral cortex at 3 days following HI (Figure 4 B,C and Figure S4B–D). thomas m sawyer