2024 Folylpolyglutamate

Folylpolyglutamate

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Tīmeklis2024. gada 10. janv. · Among the identified genes, we discovered MET7, which encodes folylpolyglutamate synthetase (FPGS), an enzyme that facilitates several folate-dependent reactions including the synthesis of purines, thymidylate (dTMP) and DNA methylation. Here, we found that Met7-deficient strains show elevated mutation … Tīmeklis2011. gada 13. janv. · A recessive Arabidopsis (Arabidopsis thaliana) mutant with short primary roots and root hairs was identified from a forward genetic screen.The disrupted gene in the mutant encoded the plastidial isoform of folylpolyglutamate synthetase (FPGS), previously designated as AtDFB, an enzyme that catalyzes the addition of …

Role of Folylpolyglutamate Synthetase and …

Tīmeklis1989. gada 1. janv. · The tissue folates exist primarily as polyglutamate derivatives with the glutamate moieties linked by γ-carboxyl peptide bonds. The chapter also … Tīmeklis1999. gada 1. marts · The polyglutamylation defect in T-ALL and AML cells was associated with a lower activity of folylpolyglutamate synthetase (FPGS), the … clough gaa

Role of Folylpolyglutamate Synthetase and ... - ScienceDirect

TīmeklisRole of folylpolyglutamate synthetase in the regulation of folate and antifolate metabolism. was published in 9 Zurich, Switzerland, September 3–8, 1989 on page 891. Tīmeklis2024. gada 5. marts · Summary. This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the … Tīmeklis1989. gada 1. janv. · The tissue folates exist primarily as polyglutamate derivatives with the glutamate moieties linked by γ-carboxyl peptide bonds. The chapter also discusses the regulation of folylpolyglutamate synthesis by physiological and nutritional factors modulated by intracellular folate levels and the types of folylpolyglutamates in tissues. clough gardens haslingden

National Center for Biotechnology Information

Biosynthesis of polyglutamates of folates - PubMed

TīmeklisFolylpolyglutamate synthetase (FPGS) catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the … Tīmeklis2015. gada 21. dec. · Given the link between the C1 and phenylpropanoid pathways, we evaluated whether folylpolyglutamate synthetase (FPGS), an enzyme that … clough garageTīmeklis2013. gada 16. aug. · This drug is converted intracellularly into polyglutamate derivates by the enzyme folylpolyglutamate synthase (FPGS). MTX polyglutamates show an enhanced and prolonged cytotoxicity in comparison ... clough gaming

"TīmeklisFolylpolyglutamate synthetase (FPGS) catalyzes the synthesis of the poly-gamma-glutamate forms of tetrahydrofolate and its co-enzyme adducts, as well as of the … " - Folylpolyglutamate

Folylpolyglutamate

Tīmeklis1999. gada 1. marts · The polyglutamylation defect in T-ALL and AML cells was associated with a lower activity of folylpolyglutamate synthetase (FPGS), the … Tīmeklis1997. gada 1. janv. · COSSINS Although folylpolyglutamate synthase activity (FPGS, EC 6.3.2.17) has been reported from a number of different plant species, 1-4 only that from pea seeds has been purified and characterized. 5'6 H4PteGlun + ATP + L-glutamate ~ H4PteGlun+l + ADP + Pi Assay Method Principle. The assay is based …

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TīmeklisThis gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial … TīmeklisFolylpolyglutamate synthase is a major determinant of intracellular methotrexate polyglutamates in patients with rheumatoid arthritis

Tīmeklis2024. gada 29. sept. · folylpolyglutamate (plural folylpolyglutamates) ( biochemistry ) A folyl derivative of polyglutamate that has a biochemical role in the central nervous … TīmeklisFolylpolyglutamate synthetase, which is responsible for the addition of a polyglutamate tail to folate and folate derivatives, is an ATP-dependent enzyme isolated from eukaryotic and bacterial ...

Tīmeklis1999. gada 1. marts · The polyglutamylation defect in T-ALL and AML cells was associated with a lower activity of folylpolyglutamate synthetase (FPGS), the enzyme that catalyzes the polyglutamate chain formation, as compared with c/preB-ALL cells.14 The difference in FPGS activity was not associated with a decreased FPGS mRNA … Tīmeklis2024. gada 5. marts · Summary. This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both …

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clough gatechTīmeklisWith the recent introduction of sensitive assays this folylpolyglutamate synthetase has begun to be characterized. Although procaryotic and eucaryotic synthetases have many dissimilar properties, both types catalyze the ATP-dependent addition of L-glutamate to the gamma-carboxyl of the glutamate present in the folate. Both types also require a ... c4d dll load failedTīmeklis2014. gada 7. jūl. · Interactions among metabolic pathways are important in plant biology. At present, not much is known about how folate metabolism affects other metabolic pathways in plants. Here we report a T-DNA insertion mutant (atdfb-3) of the plastidial folylpolyglutamate synthetase gene (AtDFB) was defective in seed … clough gate oakworthTīmeklis2024. gada 2. marts · Processes. one-carbon metabolic process. General Function. Tetrahydrofolylpolyglutamate synthase activity. Specific Function. Conversion of folates to polyglutamate derivatives. It prefers 5,10-methylenetetrahydrofolate, rather than 10-formyltetrahydrofolate as folate substrate. Pfam Domain Function. Mur_ligase_C ( … c4d downloadsTīmeklisThe purification and properties of folylpolyglutamate synthetase from Corynebacterium sp, and some properties of partially purified enzyme from Lactobacillus casei, … c4d download shaTīmeklis1997. gada 1. janv. · Although folylpolyglutamate synthase activity (FPGS) has been reported from a number of different plant species, only that from pea seeds has been … cloughglassTīmeklis2024. gada 1. jūn. · Folylpolyglutamate synthetase (FPGS) catalyzes a biochemical reaction that leads to the formation of folylpolyglutamate, an important cofactor for many enzymes in the C1 pathway. In this study ... clough ga tech