WebDec 4, 2014 · The major ligand for P-selectin is P-selectin glycoprotein ligand-1 (PSGL-1, CD 162), constitutively expressed by leukocytes. It, together with CD44, can bind to E-selectin and L-selectin [ 6 ]. E-selectin and P-selectin are expressed on the cell-surface of endothelial cells by pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 [ 7 ]. WebSelectins are a family of transmembrane proteins containing an amino-terminal lectin domain for binding to ligands, an epidermal growth factor (EGF)-like domain, 2–9 regulatory protein repeats, a transmembrane domain, and a short cytoplasmic tail.

Identification of Leukocyte E-Selectin Ligands, P-Selectin Glycoprotein …

WebBackground P-selectin glycoprotein ligand-1 (PSGL-1/CD162) has been studied extensively for its role in mediating leukocyte rolling through interactions with its cognate receptor, P … WebP-selectin is stored in platelet α-granules in resting platelets. When activated, platelets incorporated P-selectin into the plasma membrane where it becomes available for interaction with its binding partners, e.g., P-selectin glycoprotein ligand-1 (PSGL-1) on neutrophils and monocytes (Figure 1) ( 7, 45 – 49 ). family it sharing blogspot

Frontiers P-Selectin Glycoprotein Ligand 1: A Potential HIV-1

WebPSGL-1 proteins engage a diverse array of ligands at steady state and at different stages of the immune response. While multiple PSGL-1 ligands have been identified, the selectins were the first to be characterized and the most widely studied ( 51 ). WebJun 21, 2009 · Laszik, Z. et al. P-selectin glycoprotein ligand-1 is broadly expressed in cells of myeloid, lymphoid, and dendritic lineage and in some nonhematopoietic cells. Blood 88, … WebP-Selectin (CD62P), previously termed PADGEM or GMP-140, is a single chain glycoprotein of 140 kDa expressed in platelets and endothelial cells. In platelets, P-selectin is stored in … family it\\u0027s all relative