WebMar 4, 2024 · ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To … WebSep 2, 2008 · Previous studies suggested that primary cilia mediate sonic hedgehog (Shh) signaling. Here, we find that loss of ALNP cilia leads to abrogated Shh activity, increased cell cycle exit, and morphological abnormalities in ALNPs. Processing of Gli3, a mediator of Shh signaling, is also altered in the absence of cilia.
Rab8 and TNPO1 are ciliary transport adaptors for GTPase Arl13b …
WebMar 17, 2024 · There are three known mammalian Hh ligands, Sonic-Hedgehog, Indian-Hedgehog, and Desert-Hedgehog. The primary cilium is required to organize canonical … WebPrimary cilia are antenna-like cell structures that protrude in a single copy from the surface of most vertebrate cell types to detect extracellular cues that regulate embryonic … botany way rm19 1sr
Amyloid-β interrupts canonical Sonic hedgehog signaling by …
WebApr 4, 2012 · Primary cilia are nearly ubiquitous, at least in vertebrate cells, and it has become apparent that they play an essential role in the intracellular transduction of a range of stimuli. Most notable among these is Sonic Hedgehog. In this article we briefly summarize the structure and biogenesis of primary cilia. WebAug 1, 2010 · The Hedgehog signalling pathway. The Hedgehog signalling pathway was originally defined in Drosophila, and many of the core components are conserved between species.A number of excellent recent reviews have elaborated the details of the pathway (Jiang and Hui, 2008; Varjosalo and Taipale, 2008; Wong and Reiter, 2008; Simpson et al, … WebA compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene. 2024;36(43):5969–5984. 5. Egeberg DL, Lethan M, Manguso R, et al. Primary cilia and aberrant cell signaling in epithelial ovarian cancer. Cilia. 2012;1(1):15. 6. botany way nunthorpe